Eisa Mahyari, Ph.D.

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CORE SKILLS

Management Statistics & Computer Science Biology & Medicine
- Project coordination - Statistical modeling, machine learning, and artificial intelligence - Immunology, autoimmunity, and sex-biased immune function
- Operational and cross-functional leadership - Large language model adaptation and evaluation (fine-tuning, benchmarking) - Reproduction, fertility, and hormonal regulation
- Multi-disciplinary collaboration - Image-based (histology, radiology) analysis and artificial intelligence development - Infectious diseases (HIV, Mycobacterium tuberculosis, yellow fever, dengue, Zika, cytomegalovirus, SARS-CoV-2)
- Data-driven strategic planning and consultation - Software engineering (reproducible pipelines, testing, packaging) - Single-cell and spatial omics
- Budgeting and resource allocation - High performance computing and cloud (Slurm, Amazon Web Services, Google Cloud) - Vaccines and immunotherapeutics: response profiling and correlates of protection
- Stakeholder communication - Translational and clinical trial data analytics (endpoints, biomarkers, real-world data) - Host–pathogen interactions and mucosal immunity
- Grant writing (academia; Small Business Innovation Research and Small Business Technology Transfer) - Physiologically based pharmacokinetic modeling and pharmacokinetics - Biomarkers and assay development (flow cytometry, serology, multi-omics integration)
- Mentorship and supervision (students, junior scientists, analysts) - Causal inference and study design (power analysis, confounding control) - Inflammation biology and immune signaling networks
- Research-to-industry translation (requirements, milestones, deliverables) - Model interpretability and validation (calibration, robustness, external validation) - Clinical immunology and human cohort studies (study design, sample handling constraints)

Summary Statement

I am a computational biologist and technical leader focused on applied machine learning (ML) and artificial intelligence (AI) for translational biomedical research. Currently, I lead the ML/AI and spatial omics projects at the Vaccine and Gene Therapy Institute (VGTI), directing technical strategy, building reproducible analysis systems, and supervising junior computational scientists.

My work spans statistical inference, high-dimensional multi-omics integration (single-cell and spatial transcriptomics and proteomics), and development of deployable analytical tools (pipelines, interactive visualizations, and research software). In biology and medicine, I specialize in immunology, infectious diseases, and reproductive biology, translating complex experimental questions into validated computational methods and actionable biological insights.

I am most effective at bridging science and engineering: setting rigorous evaluation standards, creating scalable workflows, communicating results to cross-disciplinary teams, and driving adoption of computational products in active research programs.

Domains of Research Expertise & Interest

Technical skills

Professional Experience

2024 - Present

Lead Computational Biologist, AI & Spatial Omics (Research Assistant Professor) Lab of Jacob D. Estes, Ph.D. — Vaccine & Gene Therapy Institute (VGTI), Oregon National Primate Research Center (ONPRC), Oregon Health & Science University (OHSU)

2022 - 2024

Research Assistant Professor, Computational, OMICs, Translational Mammalian Reproduction
Lab of Donald F. Conrad, Ph.D. - Division of Genetics, ONPRC-OHSU

2018 - 2022

Computational Biologist, Molecular Immunopathology - Research Associate
Lab of Benjamin N. Bimber, Ph.D. - Primate Genetics, ONPRC-OHSU

2021 - 2022

Biostatistics & Computational Biology Consultant
Drug Development & Testing for Nonalcoholic Steatohepatitis (NASH) - CytoDyn, USA

2018 - 2022

Computational Biologist, Reproductive Biology - Research Associate
Lab of Donald F. Conrad, Ph.D. - Reproductive Genetics, ONPRC-OHSU

2016 - 2018 Doctoral Candidate, DMICE-BCB, OHSU. Developed novel machine learning framework for automated classification of rare cells in single-cell RNA-seq data. 2013 - 2016 Doctoral Student, DMICE-BCB, OHSU.

Research Involvement:

2008 - 2012 Sr. Research Associate, Louis Picker M.D., Vaccine & Gene Therapy Institute (VGTI), OHSU. Contribution: Performed experiments, analyzed flow cytometric data, performed statistical tests and developed reports and presentation materials.

2005 - 2007 Research Associate, Clinical Research Investigative Studies Program (CRISP) and Critical Care Academics Associates Program (CCAAP), OHSU. Contribution: Acquired clinical data from patient charts for ongoing studies and identified candidates for enrollment into qualifying research in the emergency department and the intensive care units.

Personal & Professional Attributes

Education

Software & Research Products

Awards and Honors

Accepted Abstracts, Poster, & Talks

Teaching & Mentorship Experience

Publications by year

Professional Affiliations

Attended Professional Conferences

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